Search on: MATURATION-PROMOTING FACTOR 
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Descriptor English:   Maturation-Promoting Factor 
Descriptor Spanish:   Factor Promotor de Maduración 
Descriptor Portuguese:   Fator Promotor de Maturação 
Synonyms English:   Histone H1 Kinase, M-Phase-Specific
M Phase-Promoting Factor
Mitosis-Promoting Factor  
Tree Number:   D08.811.913.696.620.682.700.200.580
D12.644.360.250.580
D12.776.167.200.580
D12.776.476.250.580
Definition English:   Protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2. 
Indexing Annotation English:   DF: MPF
See Related English:   Cyclins
 
History Note English:   91; HISTONE H1 KINASE, M-PHASE-SPECIFIC was HISTONE H1 KINASE, M PHASE-SPECIFIC 1991-93 
Allowable Qualifiers English:  
administration & dosage adverse effects
agonists antagonists & inhibitors
analysis biosynthesis
blood cerebrospinal fluid
chemistry classification
chemical synthesis contraindications
drug effects deficiency
diagnostic use economics
genetics history
immunology isolation & purification
metabolism pharmacology
physiology pharmacokinetics
poisoning radiation effects
supply & distribution secretion
standards toxicity
therapeutic use urine
Record Number:   29039 
Unique Identifier:   D016200 

Occurrence in VHL:
 

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